The osmolality of the reconstituted solution of meropenem for injection usp and sodium chloride injection usp is approximately 356 mosmolkg for the 500 mg dose. Meropenem and its metabolite are readily dialyzable and effectively removed by hemodialysis. Each vial contains 50 mg of amphotericin b, usp, intercalated into a liposomal membrane consisting of approximately 0. Merrem is also used to treat bacterial meningitis infection that causes inflammation of the tissue that covers the brain and spinal cord important information. Megestrol acetate is a white, crystalline solid chemically designated as 17. I g per vial meropenem injection, usp l 500 mg per lempenem injection, usp i.
Determination of meropenem in bacterial media by lcmsms. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for dilantin phenytoin. Consider the developmental and health benefits of breastfeeding along with the mothers clinical need for meropenem and any potential adverse effects on the breastfed child from meropenem. Before you receive merrem, tell your doctor if you have a history of allergies to any antibiotic medications. Product profile mylan better health for a better world. Highlights of prescribing information these highlights do not include all the information needed to use cancidas safely and effectively. Once reconstituted, meropenem iv dosing or infusion solution can only be stored for 2 hours at concentrations up to 50 mgl at temperatures of 1525 c per the manufacturer merrem. Antimicrobial activity ambisome has shown in vitro activity comparable to amphotericin b against the following organisms. Merrem is used to treat severe infections of the skin or stomach. In order to monitor the safety of astrazeneca products, we encourage reporting any side effects experienced while taking an astrazeneca product to the az information center at 18002369933. The package insert provides recommended dosage adjustments for those with renal insufficiency. Use strict aseptic techniques throughout the insertion procedure see warnings and precautions 5. Megace megestrol acetate, usp oral suspension description megace megestrol acetate, usp oral suspension contains megestrol acetate, a synthetic derivative of the steroid hormone, progesterone. Priftin is only recommended for the treatment of active pulmonary tuberculosis caused by drugsusceptible organisms as part of regimens consisting of a 2month initial phase followed by a 4month continuation phase.
Meropenem and imipenemcilastatin are carbapenem antimicrobials recommended by the infectious diseases society of america and the national comprehensive cancer network for the empiric treatment of febrile neutropenia 1,2. Is it safe to use carbapenems in patients with a history. Aspergillus fumigatus, aspergillus flavus, candida albicans, candida krusei, candida lusitaniae. Mesnex mesna is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide. While neither agent is fdaapproved for the empiric therapy of febrile neutropenia, imipenemcilastatin at a dose of 500mg q6h holds fda approval for. Is it safe to use carbapenems in patients with a history of. Alternatively, you can report any side effects of prescription drugs directly to the fda. We performed a retrospective, singlecenter, observational cohort study evaluating patients treated with imi500q6 infused over 60 minutes from september 1, 2005, to august 31, 2006, and meropenem infused over 30 minutes mero1q8 or mero500q6 from september 1, 2006, to august 31, 2007. Highlights of prescribing information these highlights. Zosyn is a monosodium salt of piperacillin and a monosodium salt of tazobactam containing a. Feraheme ferumoxytol for iron deficiency anemia home. Adverse effects adverseeffects adverseevent avycaz merrem vomiting 5% 2% nausea 3% 2% pruritus 2% 1% dizziness 2% 1% abdominalpain 1% 1%.
Jan 24, 2017 the standard dose for meropenemmerrem is 500 mg 1 g iv q8h. Before you receive merrem, tell your doctor if you have a. Vial closure drug vial 20 mm vial cover breakaway seal inside port tube bag drug vial closure vial cover 20 mm minibag plus container drug vial adaptor foil cover administration port protector breakaway seal inside port tube bag drug vial closure vial cover 20 mm minibag plus container drug vial adaptor. Meropenemvaborbactam photo key points meropenemvaboractam vabomere, formerly carbavance is the combination of carbapenem meropenem plus betalactamase inhibitor vaborbactam meropenem interferes with bacterial cell wall synthesis in susceptible pathogens through interference with penicillin binding proteins vaborbactam alone has no antimicrobial activity and is a. Acsi086f00 technical specif acsi086f00 is 106 cc zambon reference gsq. Meropenem compatibility reconstitution and stability wikidoc. Merrem is also used to treat bacterial meningitis infection that causes inflammation of the tissue that covers the brain and spinal cord. Do not use if the seal of the sterile package is broken or appears compromised.
Merrem iv meropenem for injection, for intravenous use. Oct 18, 2017 the recommended dosage is 4 g 2 g meropenem plus 2 g vaborbactam every 8 hours, with each dose provided as a 3hour infusion. Jun 26, 2019 merrem meropenem is an antibiotic that fights bacteria. The maximum loading dose and the daily maintenance dose should not exceed 70. Minibag plus container system infusion solutions, inc. Each 500 mg meropenem for injection in the duplex container will deliver 500 mg of meropenem and a total sodium content of 245. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are. Nov 22, 2016 gentamicin sulfate, a watersoluble antibiotic of the aminoglycoside group, is derived from micromonospora purpurea, an actinomycete. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for merrem meropenem skip to. Many patients who received xyrem during clinical trials in narcolepsy were receiving central nervous system.
The standard dose for meropenemmerrem is 500 mg 1 g iv q8h. Meropenem fda prescribing information, side effects and uses. Barnesjewish hospital is a 1,250 bed tertiary care center in st. This is based on results in animals with other known arteriolar irritants. Complicated urinary tract infections cuti, including pyelonephritis 1. The recommended dosage is 4 g 2 g meropenem plus 2 g vaborbactam every 8 hours, with each dose provided as a 3hour infusion. Adult patients with severe renal impairment creatinine clearance 30 mlmin1. Mirena is supplied within an inserter in a sterile package see figure 1 that must not be opened until required for insertion see description 11. Vial closure drug vial 20 mm vial cover breakaway seal inside port tube bag drug vial closure vial cover 20 mm minibag plus container drug vial adaptor foil cover administration port protector breakaway seal inside port tube bag drug vial closure vial cover 20 mm minibag plus container.
The active ingredient, mesna, is a synthetic sulfhydryl compound designated as sodium2mercaptoethane sulfonate with a molecular formula of c 2 h 5 nao 3 s 2 and a molecular weight of 164. Dec 17, 2018 mesnex mesna is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for merrem meropenem. Gentamicin sulfate, a watersoluble antibiotic of the aminoglycoside group, is derived from micromonospora purpurea, an actinomycete it has the following structural formula. See full prescribing information for complete boxed warning. Invanz ertapenemfor injection for intravenous iv or intramuscular im use initial u.
The package insert states that there is no proven successful management of extravasation after it occurs, although sympathetic block and heparinization are commonly employed during acute management. Product monograph pr meropenem for injection 500 mg and 1 g meropenem as meropenem trihydrate per vial for intravenous use sterile house std. Merrem iv meropenem for injection, for intravenous use initial u. Merrem iv is supplied in 20 ml and 30 ml injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively. Antibiotik meropenem pdf carbapenems eg, imipenem, meropenem and the monobactam antibiotic aztreonam are generally reserved for serious infections caused by. See full prescribing information for drug compatibilities. Meropenem for injection, usp is a sterile, pyrogenfree, synthetic, carbapenem antibacterial for intravenous administration. So, there could, indeed, be potential for higher doses of meropenem to maximize efficacy, all the while staying on safe ground. Jun 15, 2014 meropenem is commercially available as single use clear glass bottles contacting 500 mg or 1 g sterile meropenem powder merrem astrazeneca. The mean baselinecorrected serum calcium for the aredia 60mg and etidronate disodium groups were. Invanz may be used for the treatment of infections in adult patients with renal impairment. Pharmacokinetic and pharmacodynamic profiles of antibiotics are important in determining effective dosing regimens. In clinical trials at recommended doses, obtundation and clinically significant respiratory depression occurred in adult patients treated with xyrem see warnings and precautions 5. Ambisome amphotericin b liposome for injection description ambisome for injection is a sterile, nonpyrogenic lyophilized product for intravenous infusion.
Merrem meropenem dose, indications, adverse effects. To reduce the development of drugresistant bacteria and maintain the effectiveness of. Patients on hemodialysis should receive doses after hemodialysis sessions. Gentamicin injection is a sterile, nonpyrogenic, aqueous solution for parenteral administration and is available both with and without preservatives. Clostridium difficileassociated diarrhea clostridium difficile associated diarrhea cdad has been reported with use of nearly all antibacterial agents, including merrem i. Oct, 2019 antibiotik meropenem pdf carbapenems eg, imipenem, meropenem and the monobactam antibiotic aztreonam are generally reserved for serious infections caused by. The concomitant use of valproic acidsodium valproate and meropenem for injection is not recommended see drug interactions. The package inserts for both merrem meropenem and primaxin imipenemcilastatin list a warning stating that serious and occasionally fatal hypersensitivity anaphylactic reactions have been reported in patients receiving therapy with betalactams. The dry powder should be stored at controlled room temperature 2025c 6877f see usp. Feraheme is indicated for the treatment of iron deficiency anemia ida in adult patients. In patients whose creatinine clearance is 30 mlmin1. Priftin should not be used in the treatment of active pulmonary tuberculosis caused by rifampinresistant strains. Highlights of prescribing information take with food.
Never give anything by mouth to an unconscious person. So, there could, indeed, be potential for higher doses of meropenem to maximize efficacy, all. Infusion to reduce the development of drugresistant bacteria and maintain the effectiveness of. Mylan manufactures piperacillin and tazobactam for injection, usp zosyn in strengths of 3 g375 mg. Meropenemsold under the brandname merrem among others, is a broadspectrum antibiotic used to treat antibitik variety of bacterial infections. Indications and usage merrem iv is a penem antibacterial indicated for the treatment of. Although minimum inhibitory concentration mic data reflect microbial susceptibility to an antibiotic, they do not provide dosing information.
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